The relationship between a lysozyme-like enzyme and frog adenocarcinoma.

The occurrence of macromolecular change accompanying differentiation in embryonic or neoplastic development is well recognized, even if poorly understood.'+ In the course of immunochemical studies on macromolecular changes related to differentiation in the amphibian,".' we have had occasion to examine the antigenic composition of the f rog kidney and of the f rog renal adenocarcinoma, which is believed to be of viral origin.", I" The following is a report of observations on antigenic differences between the normal and tumor kidney of the frog, on the possible identity of one of these antigens, and on some differences between tumor-susceptible and resistant f rogs.1'-*3